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Cozaar

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Drug Name


Cozaar (Losartan)

Drug Uses


Losartan indicated for the treatment of hypertension. It may be used alone or in combination with other agents. It has less effect in black patients, as well as ACE inhibitors, such as captopril (Capoten), enalapril (Vasotec), and lisinopril (Zestril).

As Taken


Losartan can be done with or without food. Losartan metabolized in the liver by cytochrome P450 enzymes to an active metabolite that is responsible for most of the drug activity. Reducing the dose of 50% is suggested in patients with liver function violations.

Drugs and the mechanism of class


Losartan and its primary metabolite block the angiotensin receptor found in many tissues, especially in the vascular smooth muscle. Angiotensin, formed by the action of angiotensin-converting enzyme (ACE), a powerful chemical that causes narrowing of blood vessels (vasoconstriction), which can lead to elevated blood pressure (hypertension).

Missed dose


Take the missed dose as soon as you remember. However, if practicable time for the next dose, the missed dose and take only the next regular dose. Do not take a double dose of the drug.

Custody


Tablets should be stored at room temperature in tightly closed, the light resistant container.

Warnings / Precautions


Use caution when driving, operating machinery, or performing other hazardous activities. Losartan may cause drowsiness or dizziness. If you experience drowsiness or dizziness, avoid these activities. In addition, use caution when rising from a sitting or lying position. Use alcohol cautiously. Alcohol may also lower blood pressure and increase drowsiness and dizziness when taking losartan. Do not use salt substitutes or take potassium supplements, not talking to your doctor. Losartan may affect the level of potassium in the body. When used in the second or third trimester of pregnancy, drugs, which act on the same mechanism as losartan can cause injury and even death of the fetus. Losartan should not be used during pregnancy. When pregnancy is detected, losartan should be stopped as soon as possible. Losartan is present in rat milk, and is toxic to newborn rats. It should therefore be avoided in nursing mothers

Possible side effects


The studies over 4000 patients, including 1200 is seen within 6 months and 800 within 1 year, the total number of side effects coincides with placebo. Losartan generally good. Side effects include diarrhea, muscle cramps, dizziness, insomnia, and nasal congestion.

More


Stop taking losartan and contact your doctor immediately or seek emergency medical If you have any of the following serious side effects: an allergic reaction (difficulty breathing; closing of the throat, swelling of the lips, tongue, or a person or a rash), or little or no urine . Other side effects were less severe. Continue taking losartan and talk to your doctor if you experience diarrhea or upset stomach, muscle pain or cramps, dizziness, or insomnia.Side effects, in addition to those listed here may also occur. Talk with your doctor about any side effect that seems unusual or that is especially bothersome.

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